Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

Blog Article

Summary: Habitual exercise alters the intestinal microbiota composition, which may mediate its systemic benefits.We examined whether transplanting fecal microbiota from trained mice improved skeletal muscle metabolism in high-fat diet (HFD)-fed mice.Fecal samples from sedentary and exercise-trained mice were gavage-fed to germ-free mice.After receiving fecal samples from trained donor mice for 1 week, recipient mice had elevated levels of AMP-activated protein Caster Accessories kinase (AMPK) and insulin growth factor-1 in skeletal muscle.In plasma, Cream Serum bile acid (BA) deconjugation was found to be promoted in recipients transplanted with feces from trained donor mice; free-form BAs also induced more AMPK signaling and glucose uptake than tauro-conjugated BAs.

The transplantation of exercise-acclimated fecal microbiota improved glucose tolerance after 8 weeks of HFD administration.Intestinal microbiota may mediate exercise-induced metabolic improvements in mice by modifying circulating BAs.Our findings provide insights into the prevention and treatment of metabolic diseases.